TABLE 1:

Input parameters used in simulations, constrained based on experimental measurements.

Parameter	Meaning	Value	Reference
ξ	Viscous drag coefficient per unit length for longitudinal free diffusion of a MT		Imafuku et al. (1996)
γ	Effective viscous drag coefficient per attached cross-linker		Pringle et al. (2013) (We use measurements for MAP65 for an order-of-magnitude estimate of the mechanical features of the cross-linker proposed in this model.)
λ	Maximum linear density of motor attachment to MT	125 µm-1	Song and Mandelkow (1993)
doff	Cytoplasmic dynein unbinding rate under zero load	0.37 s-1	Kunwar et al. (2011)
koff	Kinesin-1 unbinding rate under zero load	0.35 s-1	Kunwar et al. (2011)
Fdd	Cytoplasmic dynein detachment force	1.74 pN	Kunwar et al. (2011)
Fdk	Kinesin-1 detachment force	2.0 pN	Kunwar et al. (2011)
Fsd	Cytoplasmic dynein stall force	2.5 pN	Kunwar et al. (2011)
Fsk	Kinesin-1 stall force	2.5 pN	Kunwar et al. (2011)
vbd	Characteristic velocity parameter for cytoplasmic ­dynein under superstall loads		Kunwar et al. (2011)
vbk	Characteristic velocity parameter for kinesin-1 under superstall loads		Kunwar et al. (2011)
vfd	Cytoplasmic dynein velocity under zero load	3.5 µm	Ahmad et al. (2006) (parameter tuned to match velocity histograms of short axonal MTs in Ahmad et al., 2006).
vfk	Kinesin-1 velocity under zero load	1.0 µm	Ahmad et al. (2006)