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. 2017 Nov 7;28(23):3360–3370. doi: 10.1091/mbc.E17-06-0408

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© 2017 Hendy et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — Core promoter mutations alter PD1 mRNA distribution and nascent transcript dynamics. (A) Representative smFISH images of B-lymphocytes probed with Cy3-labeled PD1 oligonucleotides, derived from either the WT or the indicated PD1 core promoter element mutation. (B) Binned and normalized PD1 mRNA distributions of the WT transgene in B-cells (blue, top panel; gray, remaining panels), and of the core promoter mutant transgenes (red).