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. 2017 Nov 7;28(23):3360–3370. doi: 10.1091/mbc.E17-06-0408

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© 2017 Hendy et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Bursting dynamics of PD1 core promoter mutants. (A) Fano factor vs. mean mRNA/cell of PD1 core promoter element mutants in B-lymphocytes stimulated in the absence or presence of γ-interferon. (B) A best fit curve generated from the two-state bursting telegraph model to a PD1 mRNA distribution. The two-state model can be represented as combined rates of a, a gene turning on; b, a gene turning off; and c, the rate of transcript firing with a burst. (C) Burst parameters that that satisfy the χ² null hypothesis test (p > 0.1) for the WT distribution and for the core promoter mutants. Nonoverlapping distributions indicate samples with significantly different bursting kinetics. Burst size is mRNA/cell; burst frequency is unitless.