Table 3.
Significant single variant level associations
| Trait | Gene | RS ID | SNV type | p-value | Minor allele frequency | Effect size |
|---|---|---|---|---|---|---|
| Novel associations | ||||||
| Diet protein (% energy) | PPARA | rs1800234 | missense | 1.05 ×10−7 | 0.041 | 0.632 |
| Total energy expenditure RQ | NGDN | rs2236261 | synonymous | 3.37 ×10−7 | 0.31 | 0.274 |
| Total energy expenditure RQ | NGDN | rs2236260 | synonymous | 8.94 ×10−7 | 0.35 | 0.258 |
| Serum AST (U/L) | CYB5R2 | rs61729556 | missense | 6.44 × 10−7 | 0.017 | −0.924 |
| Testosterone (ng/mL) | MUC21 | rs112415706 | missense | 6.75 × 10−7 | 0.11 | −0.408 |
| HOMA-IR | UBXN11 | rs7522905 | synonymous | 7.04 ×10−7 | 0.40 | 0.2512 |
| HDL (mg/dL) | ATP1A4 | rs76528638 | missense | 7.13 × 10−7 | 0.016 | −1.003 |
| Eotaxin (pg/mL) | ACKR2 | rs1366046 | 3′ UTR | 7.25 × 10−7 | 0.34 | −0.252 |
| Replicated associations | ||||||
| Serum MCP-1 (pg/mL) | DARC | rs12075 | missense | 8.52 × 10−27 | 0.44 | 0.533 |
| Serum MCP-1 (pg/mL) | OR10J3 | rs58037016 | missense | 3.2 × 10−7 | 0.13 | −0.363 |
| Serum IGF-1 free (ng/mL) | KLKB1 | rs3733402 | missense | 7.85 × 10−10 | 0.34 | −0.309 |
| Serum IGF-1 free (ng/mL) | KLKB1 | rs925453 | synonymous | 1.68 × 10−8 | 0.26 | −0.304 |
| Serum uric acid (mg/dL) | SLC2A9 | rs16890979 | missense | 6.1 × 10−13 | 0.39 | −0.364 |
| Serum uric acid (mg/dL) | SLC2A9 | rs13125646 | synonymous | 1.53 × 10−11 | 0.39 | 0.340 |
| Serum uric acid (mg/dL) | SLC2A9 | rs13113918 | synonymous | 1.93 × 10−11 | 0.24 | 0.387 |
| Serum uric acid (mg/dL) | SLC2A9 | rs10939650 | synonymous | 8.42 × 10−10 | 0.32 | 0.330 |
Abbreviations: RQ, respiratory quotient; AST, aspartate aminotransferase; HOMA-IR, homeostatic model assessment-insulin resistance; HDL, high density lipoproteins; Eotaxin, fasting serum eotaxin; MCP-1, monocyte chemotactic protein-1; IGF-1, insulin-like growth factor-1. Single variant significance cutoff p-value 9.2 × 10−7.