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. 2017 May 16;1(4):299–310. doi: 10.1002/hep4.1041

Figure 5.

Figure 5

Livers from HFHC‐fed CD8+ T‐cell‐depleted mice show improved steatosis. (A) Pictorial description of the experimental time line. (B) HFHC‐fed CD8+ T‐cell‐depleted mice did not show lowering of body weight gain compared to wild‐type mice fed an HFHC diet. The CD8+ T‐cell‐depleted HFHC‐fed mice had lower (C) liver TG, (D) serum ALT, and (E) expression of α‐SMA compared to HFHC‐fed wild‐type mice. (F) The CD8a mAb‐treated HFHC mice showed a lower number of infiltrating activated CD8+ T‐cells in the liver compared to HFHC‐fed wild‐type mice. The vertical bars represent mean ± SEM. Two‐way analysis of variance with Bonferroni correction for B; one‐way analysis of variance with Bonferroni correction for C‐F. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05.