Synthetic experiments. Examples of tissue excitability estimated using: 1) uniform BOBYQA, 2) adaptive BOBYQA, and 3) adaptive GPO in the presence of infarcts of varying sizes and locations (red: infarcted tissue, blue: healthy tissue). Infarct locations and sizes (in percentage ventricles covered) from top to bottom: anterior (3.17%), inferior (9.84%), and septal (24.31%).