TABLE 1.

Diabetes Medications That Tend to Increase Weight, Decrease Weight, or Are Weight Neutral

Medications That Contribute to Weight Gain	Medications That Contribute to Weight Loss	Weight-Neutral Medications
• Sulfonylureas (e.g., glipizide, glyburide, and glimepiride)	• GLP-1 receptor agonists (e.g., exenatide and dulaglutide)	• DPP-4 inhibitors (e.g., sitagliptin, saxagliptin, linagliptin, and alogliptin)
• Insulins	• Liraglutide 3.0 mg (a GLP-1 receptor agonist that is also approved for weight loss)	• α-Glucosidase inhibitors (e.g., acarbose and miglitol)
• Thiazolidinediones (e.g., pioglitazone)	• SGLT2 inhibitors (e.g., canagliflozin, dapaglifozin, and empagliflozin)	• Bile acid sequestrants (e.g., colesevelam)
• Meglitinides (e.g., nataglinide and repaglinide)	• Others (e.g., metformin and pramlintide)