Table 2.
Liver stiffness measurements and selected biochemical, hematological, and liver imaging parameters according to lifetime drinking history.
| Nondrinker (n = 46) |
Light drinker (n = 70) |
Moderate drinker (n = 35) | Crude p value |
Adjusted p valuee |
|
|---|---|---|---|---|---|
| LSM kPa a | |||||
| All | 8.4 ± 8.0 | 9.8 ± 7.1 | 10.7 ± 12.5 | 0.570 | 0.546 |
| Male | 8.7 ± 10.1 | 8.0 ± 4.8 | 12.0 ± 13.4 | 0.226 | 0.639 |
| Female | 8.2 ± 5.1 | 12.4 ± 9.8 | 4.6 ± 1.7 | 0.053 | 0.016 |
| LSM ≥ 8.2 kPa a | |||||
| All | 12 (29) | 24 (40) | 10 (30) | 0.459 | 0.302 |
| Male | 5 (24) | 14 (35) | 10 (37) | 0.584 | 0.581 |
| Femaleb | 7 (35) | 10 (50) | 0 (0) | 0.092 | 0.132 |
| CAP (dB/m) a | 322.1 ± 68.5 | 333.4 ± 54.2 | 340.6 ± 59.5 | 0.910 | 0.492 |
| ALT (IU/ml) | 36.4 ± 26.4 | 38.4 ± 29.5 | 37.4 ± 15.8 | 0.909 | 0.818 |
| AST (IU/ml) | 29.0 ± 17.6 | 28.6 ± 26.1 | 24.7 ± 11.2 | 0.606 | 0.457 |
| GGT (IU/ml) | 44.2 ± 42.9 | 53.6 ± 83.1 | 47.6 ± 45.4 | 0.738 | 0.750 |
| Platelets (×10 9) | 242.0 ± 62.6 | 229.5 ± 58.7 | 255.0 ± 45.6 | 0.095 | 0.081 |
| Albumin (g/dL) | 40.4 ± 2.8 | 40.6 ± 2.7 | 41.0 ± 3.4 | 0.704 | 0.601 |
| Spleen size (cm) c | 10.6 ± 2.9 | 10.4 ± 2.9 | 9.9 ± 3.1 | 0.666 | 0.617 |
| Liver size (cm) d | 17.3 ± 3.5 | 17.0 ± 2.3 | 17.9 ± 3.4 | 0.501 | 0.502 |
Data presented continuously (mean ± standard deviation) and analyzed using one-way ANOVA. Data presented categorically (n, %) and analyzed using Pearson's χ2 test, unless specified. aSmaller cohort of patients as LSM met quality criteria in 134 patients. bData presented categorically (n,%) and analyzed using Fisher's exact test.cSpleen size documented in 99 patients. dLiver size documented in 94 patients.eAll p values adjusted for age and BMI unless specified. ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transferase.