Table 3.
Proteins with expression change correlated to elevation of serum ALT and AST levels
| Accession | Protein | Gene symbol | Fold changea) | p-value | Biomarker applicationb) | Hepatic disease relatedb) |
|---|---|---|---|---|---|---|
| D3ZN29 | AHNAK nucleoprotein isoform 1 | AHNAK | 2.10 | 5.90 × 10−5 | ||
| P13601 | Aldehyde dehydrogenase, cytosolic 1 | ALDH1A7 | 2.01 | 3.39 × 10−2 | ||
| D3Z9Z0 | Ankyrin 1 | ANK1 | 2.23 | 4.31 × 10−5 | ||
| P47727 | Carbonyl reductase [NADPH] 1 | CBR1 | 1.62 | 3.74 × 10−2 | ||
| Q66SY1 | Clathrin-assembly lymphoid leukemia protein | PICALM | 1.43 | 1.41 × 10−3 | ||
| P45592 | Cofilin-1 | CFL1 | 2.49 | 1.73 × 10−2 | ||
| A2RRT9 | Cytochrome P450 4V3 | CYP4V2 | −1.52 | 1.49 × 10−3 | ||
| Q9WTN7 | Cytochrome P450, family 8, subfamily b, polypeptide 1 | CYP8B1 | 1.80 | 2.00 × 10−2 | ||
| Q9Z122 | Fatty acid desaturase 2 | FADS2 | −7.61 | 2.16 × 10−2 | ||
| A1L114 | Fga protein | FGA | 2.71 | 6.90 × 10−8 | ||
| Q66HT1 | Fructose-bisphosphate aldolase | ALDOB | −1.76 | 1.20 × 10−13 | × | |
| P09606 | Glutamine synthetase | GLUL | −1.45 | 3.79 × 10−9 | ||
| P0DMW0 | Heat-shock 70 kDa protein 1A/1B | HSPA1A | 55.81 | 3.40 × 10−10 | ||
| P42930 | Heat-shock protein beta-1 | HSPB1 | 50.27 | 2.89 × 10−6 | Diagnosis, efficacy | × |
| P82995 | Heat-shock protein HSP 90-alpha | HSP90AA1 | 1.45 | 7.87 × 10−6 | Safety | × |
| P06762 | Heme oxygenase 1 | HMOX1 | 23.63 | 2.77 × 10−5 | Efficacy, safety | × |
| Q0ZHH6-1 | Isoform 1 of Atlastin-3 | ATL3 | −2.10 | 4.48 × 10−4 | ||
| Q63945-2 | Isoform 2 of protein SET | SET | 1.57 | 2.20 × 10−3 | Prognosis | |
| Q3MIB4 | Lon protease homolog 2, peroxisomal | LONP2 | 1.54 | 2.39 × 10−5 | ||
| Q920P0 | L-xylulose reductase | DCXR | −1.80 | 8.45 × 10−6 | ||
| Q5XI38 | Lymphocyte cytosolic protein 1 | LCP1 | 2.35 | 9.61 × 10−3 | Disease progression | |
| D3ZS58 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | NDUFA2 | 1.47 | 3.03 × 10−2 | ||
| P50116 | Protein S100-A9 | S100A9 | 11.86 | 1.18 × 10−4 | Diagnosis | |
| Q499R7 | Pyrophosphatase 1 | PPA1 | −2.21 | 8.56 × 10−5 | ||
| D3ZA81 | SAM domain and HD domain-containing protein 1 | SAMHD1 | 1.74 | 8.88 × 10−3 | ||
| Q6AYR8 | Secernin-2 | SCRN2 | 1.65 | 1.11 × 10−3 | ||
| Q5M878 | Serum amyloid A protein | HPS5 | 2.41 | 1.05 × 10−4 | ||
| Q9WUW9 | Sulfotransferase 1C2A | SULT1C2A | −2.61 | 1.54 × 10−2 | ||
| Q63199 | Tumor necrosis factor receptor superfamily member 6 | FAS | 1.41 | 4.30 × 10−2 | Diagnosis, disease progression, efficacy | × |
| P08430 | UDP-glucuronosyltransferase 1–6 | UGT1A6 | 1.44 | 3.33 × 10−2 | ||
| Q5I034 | Uncharacterized protein C12orf43 homolog | RGD1311899 | 2.04 | 4.17 × 10−3 |
a)
Fold change listed was from dataset Dataset 5 (24 h, 1250 mg/kg APAP, elevated serum ALT and AST levels) (see Section 2). A positive fold change represents upregulation and a negative fold change indicates downregulation upon APAP treatment.
b)
Annotation from ingenuity pathway analysis.