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. Author manuscript; available in PMC: 2018 Feb 9.
Published in final edited form as: Nat Biomed Eng. 2017 Aug 9;1:644–653. doi: 10.1038/s41551-017-0117-6

Figure 1.

Figure 1

Ultrasound triggerability with PPIX-loaded liposomes. (a) Effect of PPIX loading on ROS generation (measured by fluorescent assay) by liposomes after 10-min insonation at 1 MHz, 3 W/cm2. (b) Time course of lipid peroxidation in liposomes of optimal PPIX loading (0.3 % [mg PPIX/mg (PPIX+lipid) × 100 %]) under continuous ultrasound (US) exposure (3 W/cm2, 1 MHz). See Methods for details. (c) Effect of PPIX loading in liposomes (mg PPIX/mg lipid+PPIX × 100 %) and of presence of DLPC on sulforhodamine B release after insonation (3W/cm2, continuous application, 1 MHz, 10 min). (d–f) In vitro dye release as a function of (d) ultrasound duration and frequency (3W/cm2, continuous application), (e) ultrasound intensity (10 min, 1 MHz, continuous application), and (f) duty cycle (1 MHz, 10 min, 3 W/cm2). Data are means ± SD, N=4. *P<0.05. All individual data points are listed in Table S6–S11.