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. Author manuscript; available in PMC: 2018 Feb 9.
Published in final edited form as: Nat Biomed Eng. 2017 Aug 9;1:644–653. doi: 10.1038/s41551-017-0117-6

Figure 3.

Figure 3

TTX-loaded liposomes. (a) Representative cryo-transmission electron microscopy micrograph of Lipo-PPIX-TTX. Scale bar = 200 nm. (b–c) In vitro TTX release (cumulative % of total) at 37°C from (b) Lipo-PPIX-TTX and (c) Lipo-TTX with and without ultrasound (US). Arrows represent the application of ultrasound (1 MHz, 3 W/cm2, continuous, 10 min) at the 5 h time point. Data are means ± SD, N = 4. All individual data points are listed in Table S15–S16. At 9 h of incubation, P=0.005 in panel b and P=0.39 in panel c for the comparison between samples with and without insonation.