Table 1.

Translational comparison of sub-anesthetic ketamine doses shown to produce psychotomimetic effects, antidepressant effects, and BOLD activation. Typical ketamine doses used for anesthesia are also shown.

	Common active sub-anesthetic ketamine doses (plasma concentration)	Anesthetic ketamine dose (plasma concentration)
Human	~0.5 mg/kg I.V. over 40 minutes	~1–2 mg/kg I.V.
	(50–250 ng/mL)a,b	(>1,080 ng/mL)d
Rhesus Monkey	~1 mg/kg I.M.	~10 mg/kg I.M.
	(100–200 ng/mL) c
Rat	~10 mg/kg I.P.	~100 mg/kg I.P.
	(100–300 ng/mL)c	(>2,000 ng/mL)e

^aDe Simoni et al. (2013)

^bKrystal et al. (1994)

^cShaffer et al. (2014)

^dDomino et al. (1984)

^eVeilleux-Lemieux et al. (2013)