Figure 1.

Comparison of subject DNA methylation dysregulation index, fraction of genome altered, mutation count burden, and proportion of methylation dysregulation by genomic context by cancer type. Each dot corresponds to the sample specific methylation dysregulation index-MDI, fraction of genome altered, or mutation count burden. Tumor types are ordered by their median frequency of each alteration. Overall the median MDI was similar between the compared tumors. Individual MDI were disaggregated according to the unweighted proportion contributed by each genomic context. Thyroid cancers showed the lowest alterations in all the 3 measures, while bladder was consistently highly altered in all 3 measurements. For this specific data set there were only reported 4 mutations in colon adenocarcinoma, and there was not information available for esophageal carcinoma.