Table 3.
Distinct pathways regulated by CORT in blood and hippocampus.
| KEGG Pathways in Blood | Genes in Category | Genes Observed | Genes Expected | Enrichment | P-value | Q-value |
|---|---|---|---|---|---|---|
| Metabolic pathways | 1,184 | 152 | 40.9 | 3.7 | 2.7 × 10−44 | 2.4 × 10−40 |
| Pathways in cancer | 325 | 51 | 11.2 | 4.5 | 2.1 × 10−19 | 1.9 × 10−15 |
| Acute myeloid leukemia | 57 | 21 | 2 | 10.7 | 1.2 × 10−16 | 1.1 × 10−12 |
| Neurotrophin signaling | 131 | 27 | 4.5 | 6 | 6.9 × 10−14 | 6.4 × 10−10 |
| Insulin signaling pathway | 137 | 27 | 4.7 | 5.7 | 2.2 × 10−13 | 2.0 × 10−09 |
| Endocytosis | 220 | 33 | 7.6 | 4.3 | 1.6 × 10−12 | 1.5 × 10−08 |
| Adipocytokine signaling | 68 | 18 | 2.4 | 7.7 | 1.1 × 10−11 | 1.0 × 10−07 |
| Phosphatidylinositol signaling | 78 | 19 | 2.7 | 7.1 | 1.5 × 10−11 | 1.4 × 10−07 |
| MAPK signaling pathway | 268 | 35 | 9.3 | 3.8 | 2.0 × 10−11 | 1.8 × 10−07 |
| Purine metabolism |
168 |
27 |
5.8 |
4.7 |
3.3 × 10−11 |
3.0 × 10−07 |
| KEGG Pathways in HPC |
Genes in Category |
Genes Observed |
Genes Expected |
Enrichment |
P-value |
Q-value |
| Metabolic pathways | 1,184 | 220 | 78.9 | 2.8 | 4.0 × 10−44 | 3.7 × 10−40 |
| Pathways in cancer | 325 | 104 | 21.7 | 4.8 | 7.2 × 10−43 | 6.6 × 10−39 |
| MAPK signaling pathway | 268 | 74 | 17.9 | 4.1 | 2.3 × 10−26 | 2.1 × 10−22 |
| Wnt signaling pathway | 154 | 50 | 10.3 | 4.9 | 1.1 × 10−21 | 1.0 × 10−17 |
| Calcium signaling pathway | 178 | 53 | 11.9 | 4.5 | 6.0 × 10−21 | 5.5 × 10−17 |
| Neurotrophin signaling | 131 | 42 | 8.7 | 4.8 | 3.1 × 10−18 | 2.9 × 10−14 |
| Type II diabetes mellitus | 49 | 23 | 3.3 | 7.1 | 8.8 × 10−15 | 8.1 × 10−11 |
| Axon guidance | 131 | 37 | 8.7 | 4.2 | 2.8 × 10−14 | 2.6 × 10−10 |
| Adipocytokine signaling | 68 | 26 | 4.5 | 5.7 | 6.6 × 10−14 | 6.1 × 10−10 |
| Insulin signaling pathway |
137 |
37 |
9.1 |
4.1 |
1.3 × 10−13 |
1.2 × 10−09 |
| KEGG Pathways in Blood and HPC |
Genes in Category |
Genes Observed |
Genes Expected |
Enrichment |
P-value |
Q-value |
| Pathways in cancer | 325 | 42 | 5.81 | 7.22 | 2.06E−23 | 9.78E−19 |
| Metabolic pathways | 1,184 | 68 | 21.18 | 3.21 | 6.89E−17 | 3.27E−12 |
| Acute myeloid leukemia | 57 | 17 | 1.02 | 16.67 | 1.23E−16 | 5.84E−12 |
| Pancreatic cancer | 71 | 14 | 1.27 | 11.02 | 2.95E−11 | 1.40E−06 |
| Chronic myeloid leukemia | 74 | 14 | 1.32 | 10.58 | 5.31E−11 | 2.52E−06 |
| Chemokine signaling pathway | 185 | 20 | 3.31 | 6.04 | 1.83E−10 | 8.69E−06 |
| Adipocytokine signaling | 68 | 13 | 1.22 | 10.69 | 2.25E−10 | 1.07E−05 |
| Wnt signaling pathway | 154 | 18 | 2.75 | 6.53 | 4.10E−10 | 1.95E−05 |
| Insulin signaling pathway | 137 | 17 | 2.45 | 6.94 | 4.89E−10 | 2.32E−05 |
| Neurotrophin signaling | 131 | 16 | 2.34 | 6.83 | 1.99E−09 | 9.45E−05 |