Table 4.

Multivariable linear regression models for the association of prenatal metals exposure and placental DNA methylation to NR3C1.

	Unadjusted	Adjusted
Arsenic
Low	Ref	Ref
Mid	0.71 (0.04) <0.001	0.74 (0.04) 0.001
High	0.69 (0.04) <0.001	0.71 (0.04) 0.0002
Cadmium
Low	Ref	Ref
Mid	0.71 (0.04) <0.001	0.71 (0.04) <0.001
High	0.73 (0.04) <0.001	0.74 (0.04) <0.001
Lead
Low	Ref	Ref
Mid	0.80 (0.04) 0.02	0.81 (0.04) 0.02
High	0.74 (0.04) <0.001	0.77 (0.04) 0.004
Manganese
Low	Ref	Ref
Mid	0.89 (0.04) 0.21	0.92 (0.04) 0.38
High	0.77 (0.04) 0.006	0.80 (0.04) 0.02
Mercury
Low	Ref	Ref
Mid	0.96 (0.04) 0.62	1.01 (0.04) 0.90
High	1.39 (0.04) <0.001	1.41 (0.04) <0.001
Zinc
Low	1.22 (0.04) 0.04	1.26 (0.04) 0.01
Mid	1.04 (0.04) 0.65	1.10 (0.04) 0.32
High	Ref	Ref
Cumulative Risk
Low	Ref	Ref
Mid	1.03 (0.04) 0.7862	1.02 (0.04) 0.81
High	0.83 (0.04) 0.04	0.86 (0.04) 0.09

Top cell entries β (SE), bottom cell entry P-value. Adjusted models control for maternal age, race, education, pre-pregnancy BMI, prenatal tobacco use, prenatal depression, infant gender, and birthweight percentile. High, Mid, and Low levels of exposure correspond to tertiles of the distributions for each metal.