Table 5.
Regression of M-value on neighborhood social environment in inflammation pathway genes (n = 1,226).
|
CCL1 |
CD1D |
F8 |
KLRG1 |
NLRP12 |
SLAMF7 |
TLR1 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | ||
| Neighborhood Social Environment | −0.025 (0.007) |
0.0003 | 0.008 (0.003) |
0.001 | 0.061 (0.017) |
0.0003 | −0.018 (0.008) |
0.023 | 0.017 (0.005) |
0.001 | −0.003 (0.006) |
0.631 | 0.023 (0.005) |
2.1E-05 | |
| Promoter | 1.684 (0.008) |
<2.0E-16 | 2.652 (0.008) |
<2.0E-16 | 1.685 (0.008) |
<2.0E-16 | 0.499 (0.009) |
<2.0E-16 | −0.162 (0.008) |
<2.0E-16 | 4.934 (0.008) |
<2.0E-16 | 4.078 (0.007) |
0.256 | |
| Shore/Shelf | — | — | −4.650 (0.004) | <2.0E-16 | −1.351 (0.024) |
<2.0E-16 | — | — | — | — | — | — | — | — | |
| Neighborhood Social Environment* Promoter | 0.049 (0.008) |
2.7E-10 | 0.032 (0.007) |
0.001 | 0.016 (0.007) |
0.031 | 0.034 (0.009) |
0.0001 | −0.016 (0.008) |
0.042 | 0.029 (0.008) |
0.001 | −0.019 (0.007) |
0.010 | |
| Neighborhood Social Environment* Shore/Shelf | — | — | −0.014 (0.004) | 1.5E-05 | −0.084 (0.023) |
0.0003 | — | — | — | — | — | — | — | — | |
Regression models control for age, sex, race/ethnicity, childhood SES, adult SES, and enrichment scores for each of 4 major blood cell types (neutrophils, B cells, T cells, and natural killer cells). Higher values indicate worse neighborhood social environment. Asterisks (*) indicate interaction terms.