Table 7.
Enrichment of DNA methylation sites from 18 stress reactivity and inflammation genes in top results from epigenome-wide analyses for neighborhood characteristics (n = 1,226).
| Neighborhood Characteristic | Top Percentage of EWAS Results | Enrichment for Stress Reactivity Genes (P-valuea) | Enrichment for Inflammation Genes (P-valuea) |
|---|---|---|---|
| Socioeconomic Disadvantage | 1% | 0.309 | 0.591 |
| 2% | 0.347 | 0.834 | |
| 5% | 0.035 | 0.656 | |
| Social Environment | 1% | 0.858 | 0.012 |
| 2% | 0.980 | 0.009 | |
| 5% | 0.506 | 0.077 |
Stress reactivity genes include 194 methylation sites in 7 genes. Inflammation genes include 89 methylation sites in 11 genes.
a
P-value from one-sided Fisher's Exact Test for enrichment of stress reactivity/inflammation genes in top epigenome-wide association study (EWAS) results.