Table 4.
Selected examples of tumor-specific promoters
| Tumor target | Virus-encoded promoter | Viral platform | References |
|---|---|---|---|
| Bladder cancer | Uroplakin II | Ad | 131 |
| Brain tumors | Nestin | HSV-1 | 132 |
| Musashi-1 | HSV-1 | 133 | |
| Breast cancer | Estrogen response element | Ad | 134 |
| Gastroenteropancreatic neuroendocrine tumors | Chromogranin-A | Ad | 135 |
| Glioma | Glial fibrillary acidic protein | Ad | 136 |
| Hepatocellular carcinoma | Alpha-fetoprotein | Ad, HSV-1 | 137 |
| Melanoma | Tyrosinase | Ad | 138 |
| Mesothelioma | Mesothelin | Ad | 139 |
| Ovarian cancer and breast cancer | Mucin-1 | Ad | 140 |
Abbreviations: Ad, adenovirus; HSV-1, herpes simplex virus-1.