Table 3.

Correlations between biomarkers and imaging characteristics among genotype-positive individuals

	NT-proBNP		hsTnI		Soluble ST2		Galectin-3		Periostin
	Beta (SE)	p Value	Beta (SE)	p Value	Beta (SE)	p Value	Beta (SE)	p Value	Beta (SE)	p Value
LA diameter	0.67(0.12)	<0.0001	0.64 (0.11)	<0.0001	0.14 (0.12)	0.22	0.22 (0.13)	0.09	0.11 (0.12)	0.35
LVEDD z-score	−0.14 (0.06)	0.018	−0.01 (0.06)	0.91	0.01 (0.05)	0.79	0.03 (0.07)	0.61	0.04 (0.06)	0.58
LVESD z-score	−0.12 (0.06)	0.033	0.02 (0.05)	0.72	0.02 (0.05)	0.68	0.04 (0.06)	0.49	0.02 (0.05)	0.67
LVWT z-score	0.11 (0.01)	<0.0001	0.06 (0.01)	<0.0001	−0.01 (0.01)	0.59	0.01 (0.02)	0.63	0.02 (0.01)	0.15
LVEF, %	0.01 (0.01)	0.20	−0.002 (0.01)	0.84	−0.002 (0.01)	0.79	−0.02 (0.01)	0.09	0.001 (0.01)	0.96
E/A ratio	−0.19 (0.14)	0.19	−0.34 (0.15)	0.03	−0.10 (0.13)	0.45	−0.49 (0.14)	0.001	0.03 (0.16)	0.84
Deceleration time	0.0004 (0.002)	0.81	0.004 (0.002)	0.02	0.002 (0.001)	0.06	0.002 (0.002)	0.23	−0.002 (0.002)	0.21
Global e' z-score	−0.21(0.02)	<0.0001	−0.16 (0.02)	<0.0001	0.01 (0.03)	0.65	−0.05 (0.03)	0.15	−0.03 (0.03)	0.21
Global s' z-score	−0.20 (0.05)	0.0002	−0.13 (0.04)	0.003	0.08 (0.03)	0.02	−0.04 (0.05)	0.42	−0.07 (0.04)	0.10
CMR LGE, %	0.07 (0.01)	<0.0001	0.02 (0.01)	0.02	0.02 (0.01)	0.03	0.01 (0.01)	0.24	0.07 (0.01)	<0.001
Exercise duration	−0.13 (0.03)	0.0001	−0.04 (0.03)	0.15	0.01 (0.03)	0.66	−0.03 (0.03)	0.31	−0.03 (0.03)	0.40
Peak MET	−0.12 (0.02)	<0.0001	−0.05 (0.03)	0.07	0.02 (0.02)	0.46	−0.05 (0.03)	0.12	−0.03 (0.03)	0.19

Beta coefficient represents the change in imaging characteristic per 1 SD increase in log-transformed biomarker, after adjustment for age, sex and familial correlation.

CMR, cardiac MRI; hsTnI, high-sensitivity troponin I; LA, left atrial; LGE, late gadolinium enhancement; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic dimension; LVWT, left ventricular wall thickness; MET, metabolic equivalent; NT-proBNP, N-terminal pro-B-type natriuretic peptide.