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. 2017 Apr 1;1(2):153–167. doi: 10.1002/hep4.1027

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© 2017 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effect of LKB1 and PTEN loss on ductal plate formation in the liver. (A) Gene enrichment analysis shows that expression of genes involved in the Notch signaling pathway is enriched in the Pten‐null livers versus controls. (B) qPCR analysis of selective genes in the Notch signaling pathway; n = 3; P < 0.05. (C) Keratin staining (red) showing immature ductal morphology of livers from the 3‐week‐old LKO and LPKO mice compared to the CON and PKO livers; blue, DAPI. Scale bar, 500 μm. Abbreviations: DAPI, 4',6‐diamidino‐2‐phenylindole; mRNA, messenger RNA.