Figure 5. Caspase and calpain inhibition attenuates PARP cleavage following ARDA administration in 22Rv1 cells.

Whole-cell lysates of 22Rv1 cells treated with vehicle, VNPT-178, or VNLG-74A in the absence or presence of increasing doses of the pan-caspase inhibitor Z-VAD-FMK (A) or the calpain 1 and 2 inhibitor calpeptin (B) were collected for western blot analysis. Blots are representative of at least three independent experiments.