Table 2. Genotype frequencies of TLR5 polymorphisms and their associations with breast cancer risk.
| SNP | Minor | Major | Case2 (%) | Control3 (%) | p4 for model of inheritance | OR5 (95%CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (a1) | (A) | AA | Aa | aa | AA | Aa | aa | Additive | Dominant | Recessive | ||
| rs2072493 | G | A | 292 | 176 | 48 | 270 | 197 | 53 | 0.321 | 0.132 | 0.629 | 0.828(0.649-1.058) |
| (56.6) | (34.1) | (9.3) | (51.9) | (37.9) | (10.2) | |||||||
| rs5744168 | T | C | 487 | 28 | 1 | 507 | 13 | 0 | - | 0.011 | - | 2.322(1.193-4.520) |
| (94.4) | (5.4) | (0.2) | (97.1) | (2.8) | (0) | |||||||
1Minor allele ‘a’ and the major ‘A’ are shown in the table. ‘AA’, ‘Aa’, ‘aa’ represent a given variant for each SNP genotyped.
2The number of cases in study cohort was 516.
3The number of controls in study cohort was 520.
4The p values were accessed using Plink and SPSS software under an additive model (AA vs. Aa vs. aa), dominant model (aa+Aa vs. AA), and recessive model (aa vs. Aa+AA) respectively. Significant values (P<0.05) are in bold.
5Estimated odds ratio (OR) and 95% confidence interval (CI) were assessed under a dominant model (aa+Aa vs. AA).