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. 2017 Sep 11;8(51):88658–88669. doi: 10.18632/oncotarget.20809

Figure 3. SK reduces TAM resistance of breast cancer cells by upregulating uc.57 and downregulating BCL11A and related PI3K/AKT and MAPK pathways.

Figure 3

(A) QRT-PCR analysis of uc.57 levels in MCF-7R cells treated with 0–3 µM SK. (B) QRT-PCR analysis of uc.57 expression in control, TAM, SK and SK+TAM treated MCF-7R cells. (C) QRT-PCR analysis of BCL11A mRNA expression in control, TAM, SK and SK+TAM treated MCF-7R cells. (D) Representative western blot showing expression of BCL11A, PI3K, AKT, p-AKT, MEK, p-MEK, ERK, p-ERK proteins in control, TAM, SK and SK+TAM treated MCF-7R cells. Note: *denotes P < 0.05 compared to control.