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. 2017 Sep 11;8(51):88658–88669. doi: 10.18632/oncotarget.20809

Figure 6. BCL11A knockdown reduces TAM resistance by inhibiting PI3K/AKT and MAPK signaling pathways.

Figure 6

(A) QRT-PCR analysis of BCL11A mRNA in MCF-7R-si-BCL11A and MCF-7R-si-NC cells. (B) Representative western blot showing BCL11A protein expression in MCF-7R-si-BCL11A and MCF-7R-si-NC cells. (C) Representative western blots showing PI3K, AKT, p-AKT, MEK, p-MEK, ERK, p-ERK protein expression in MCF-7R-si-BCL11A and MCF-7R-si-NC cells. (D) CCK-8 assay showing viability of MCF-7R-si-BCL11A and MCF-7R-si-NC cells with or without TAM treatment. Note: *denotes P < 0.05 compared to control; MCF-7R-si-BCL11A denotes MCF-7R cells stably transfected with siRNA against BCL11A; MCF-7R-si-NC denotes MCF-7R cells stably transfected with control siRNA.