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. 2017 Sep 12;8(51):88719–88729. doi: 10.18632/oncotarget.20838

Figure 4. Xenografs from primary tumor EG30, which contained high level of pSTAT3, was sensitive to STAT3 inhibition.

Figure 4

(A) 8 Mice bearing PDX were treated with vehicle, 5-FU, Stattic, or 5-FU+Stattic. While 5-FU alone inhibited tumor growth moderately, Stattic alone significantly inhibited the xenografts growth (**P<0.01 compared with vehicle group). (B) Photograph of tumors from the 4 groups at the end of the experiments. Weight of the xenografts were measured (*p<0.05, **p<0.01 compared with vehicle group). (C) Immunoblotting of STAT3, pSTAT3, pentraxin-3, iNOS, and Cox2 in the xenografts. Stattic markedly decreased pSTAT3 level and altered the levels of pentraxin-3, iNOS, and Cox2. (D) Histological and immunohistochemical analysis of the xenografts. Compared with control, xenografts from Stattic and Stattic plus 5-FU-treated mice contained higher levels of activated caspase-3 and TUNEL+ cells.