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. 2017 Sep 18;8(51):88730–88750. doi: 10.18632/oncotarget.20982

Figure 7. Inhibition of HDAC6 reduces fibroblast activation and ECM protein deposition in the peritoneum after exposure to high glucose dialysate.

Figure 7

Peritoneal membrane was collected at 28 days after PDF injection with or without administration of TA (70 mg/kg, daily). (A) The peritoneal tissue lysates were subjected to immunoblot analysis with specific antibodies against α-SMA or GAPDH. (B) Expression levels of α-SMA were quantified by densitometry and normalized with GAPDH. (C) The percentage of collagen I-positive areas was calculated from ten random fields of six mice peritoneal samples. (D) Photomicrographs illustrate immunohistochemical staining of collagen I in the submesothelial compact zone (original magnification, ×200). Data are represented as the means±SD (n=6). Means with different letters are significantly different from one another (P<0.05).