Table 3. Cyclin D1 expression and CCND1 amplification in breast cancer subtypes.
Subtype | Cyclin D1 Negative | Cyclin D1 <10% | Cyclin D1 10–50% | Cyclin D1 >50% | CCND1 Not A | CCND1 low A | CCND1 high A |
---|---|---|---|---|---|---|---|
Luminal A | 0 | 5 (7.3%) | 22 (32.4%) | 41 (60.3%) | 56 (82.3%) | 11 (16.2%) | 1(1.5%) |
Luminal B | 2 (3.2%) | 1 (1.6%) | 15 (23.8%) | 45 (71.4%) | 45 (71.4%) | 5 (7.9%) | 13 (20.7%) |
HER2 | 0 | 4 (30.8%) | 5 (38.5%) | 4 (30.8%) | 12 (92.3%) | 0 | 1(7.7%) |
Triple Negative | 10 (28.6%) | 11 (31.4%) | 10 (28.6%) | 4 (11.4%) | 32 (91.4%) | 1 (2.9%) | 2 (5.7%) |
Not A: not amplified, low A: amplification ≤10 signals per nuclei, high A: amplification >10 signals