Table 1. Main characteristics of all studies included in the meta-analysis.
| Author | Country/Year | Area | Tumor site | Case number | Age (years) | Gender (M/F) | Metastasis | Treatment | Follow-up (months) | Survival analysis | Cut-off value | Analysis | HR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sookyung Lee | Korea /2016 |
Eastern | Colon/rectum 88/32 |
120 | 82/38 (<65/≥ 65) |
59/61 | No/yes 45/75 |
Mixed | median 7.6 |
OS | 27 | UV | report |
| Anna Song | Korea /2015 |
Eastern | Colon/rectum 125/52 |
177 | 123/54 (<65/≥ 65) |
83/94 | No/yes 69/108 |
Mixed | median 8.3 |
OS | 27 | UV | report |
| Mitsuru Ishizuka | Japan/2016 | Eastern | Colon/rectum 418/209 |
627 | 169/458 (≤60/>60) | 400/227 | No/yes 491/136 |
surgery | median 29.9 | OS | 9.5 | MV | report |
| Yuchen Wu | China/2016 | Eastern | Colon/rectum 25/30 |
55 | 28/27 (<60/≥60) |
35/20 | No/yes 0/55 |
Mixed | NR | OS/PFS | 37 | NR | report |
| Yukiya Narita | Japan/2014 | Eastern | Colon/rectum 148/104 |
252 | Median 61 |
155/97 | No/yes 0/252 |
chemotherapy | median 36.7 | OS | 37 | MV | report |
| Jingtao Wang | China/2015 | Eastern | Colon/rectum 176/134 |
310 | 138/172 (<65/≥ 65) |
152/158 | No/yes 310/0 |
surgery | median 71 | OS/DFS | 35 | MV | report |
| Masatsune Shibutani | Japan/2015 | Eastern | Colon/rectum 131/123 |
254 | median 66 | 139/115 | No/yes 254/0 |
surgery | median 1 | OS | 37 | UV | report |
| Ondrej Fiala | Czech/2015 | Western | Colon/rectum 86/66 |
152 | median 61.1 | 104/48 | No/yes 0/152 |
Mixed | median 18.9 | OS/PFS | 28 | MV | report |
| Tsuyoshi Ozawa | Japan/2016 | Eastern | Colon/rectum 96/77 |
173 | mean 61 | 98/75 | No/yes 0/173 |
surgery | median 36.9 | OS/RFS | 37 | MV | report |
| Xian-Hua Gao | China/2013 | Eastern | Colon/rectum 217/206 |
742 | mean 60 | 423/319 | No/yes 687/55 |
surgery | median 56 | OS/DFS | 37 | MV | report |
| Z.-M Li | China/2016 | Eastern | Colon/rectum 110/0 |
110 | mean 62.9 | 58/52 | No/yes 0/110 |
surgery | median 10.4 | OS | 37 | MV | report |
| Ruixue Yuan | China/2013 | Eastern | Colon/rectum/unspecified 184/182/5 |
371 | mean 58.4 | 207/164 | No/yes 341/30 |
surgery | mean 45.3 |
OS/DFS | 37.5 | MV | report |
| Fatih Selcukbiricik | Turkey/2013 | Western | Colon/rectum 127/88 |
215 | 125/90 (≤60/>60) | 133/82 | No/yes 94/121 |
chemotherapy | median 30.8 | OS | 37 | MV | report |
| HARUNOBU SATO | Japan/2011 | Eastern | Colon/rectum 1476/0 |
1476 | 179/1296 (≤50/>50) | 881/595 | No/yes 1476/0 |
surgery | median Re/NRe 52.5/101.5 |
OS | 37 | MV | report |
| Shinya Abe | Japan/2016 | Eastern | Colon/rectum 67/62 |
129 | 60/69 (<60/≥60) |
80/49 | No/yes 0/129 |
surgery | median 33.6 |
OS/RFS | 50 | MV | SC |
| IN JA PARK | Korea /2009 |
Eastern | Colon/rectum 534/575 |
1109 | NR | 614/501 | No/yes 1109/0 |
surgery | median 48 |
DFS | 37 | MV | SC |
| Injae Hong | Korea /2015 |
Eastern | Colon/rectum 88/74 |
162 | 88/74 (≤62/>62) | 90/72 | No/yes 146/16 |
surgery | Mean 83 |
DFS | 37 | MV | report |
Abbreviation: OS overall survival, DFS disease-free survival, PFS progression-free survival, RFS relapse-free survival, HR hazard ratio, NR not report, MV Multivariate analysis, UV univariate analysis, SC survival curve.