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. 2017 Nov 15;12(11):e0187384. doi: 10.1371/journal.pone.0187384

Fig 5. Notch signaling is modulated in laser-microdissected CK19-ve population.

Fig 5

Real time PCR analysis of Notch components on CK19-ve microdissected samples showed a significant reduction, induced by MCD diet, of Notch receptors (-1 and -2) and Jag1 ligand expression in hepatocytes, respect to controls; on the contrary, the expression of Notch target genes was not altered. The expression of the Notch endogenous inhibitor Numb was strongly downregulated in hepatocytes by MCD diet. Data are expressed as 2^-dCt (n = 5 mice per group; *p<0.05, **p<0.01; ***p<0.001).