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In vitro pharmacology of SKY2-23-7 versus SHU9119 in female HEK293 cells. A Schild analysis of SKY2-23-7 at the mMC3R (A) and mMC4R (B). A Schild analysis of SHU9119 at the mMC3R (C) and mMC4R (D). SKY2-23-7 lacks the mMC3R partial agonism commonly seen with known central antagonists such as SHU9119 (A versus C). Data from Doering et. al.22
