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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: Cell Rep. 2017 Oct 24;21(4):926–933. doi: 10.1016/j.celrep.2017.09.088

Fig. 2. Phe240Leu alters [Cl−]i sensitivity and K+ selectivity of rSlick channels.

Fig. 2

Representative whole-cell current traces evoked by depolarizing steps in pipette chloride concentration of ~15 mM (left) or ~139 mM (right) of (A) WT rSlick and (C) F240L rSlick. Effect of increasing [Cl−]i concentration on current-voltage relationship of (B) WT and (D) F240L ISlick (n=7 per group). Unpaired t-test, *p<.005. Shown are mean ± SEM. (E) Scatter plot of reversal potentials (ERev) recorded in WT-, F240L- and 1:1 WT+F240L-expressing CHO cells. Bars represent mean value per group (n=12 per group). Data points reflect ERev values across both ~15 and ~139 mM [Cl−]i.