Table 2. Comparison of clinical characteristics of the Berne Amish kindred SERPINE1+/+ and CARDIA.
|
SERPINE1+/+ (n = 127) |
CARDIA (n = 2793) |
P | |
| Age (years) | 46 ± 20 | 50 ± 4 | 0.03 |
| Female, n (%) | 70 (55) | 1605 (57) | 0.60 |
| Hypertension, n (%) | 41 (33) | 1023 (37) | 0.42 |
| Systolic blood pressure (mmHg) | 130 ± 18 | 119 ± 16 | <0.01 |
| Diastolic blood pressure (mmHg) | 77 ± 10 | 75 ± 11 | 0.02 |
| Obesity, n (%) | 38 (30) | 1181 (42) | <0.01 |
| Body mass index (kg/m2) | 28 ± 6 | 30 ± 7 | <0.01 |
| Diabetes, n (%) | 8 (7) | 296 (11) | 0.17 |
| Fasting glucose (mg/dl)* | 88 (82–98) | 94 (87–102) | <0.01 |
| Total cholesterol (mg/dl) | 188 ± 40 | 192 ± 36 | 0.23 |
| HDL cholesterol (mg/dl) | 60 ± 15 | 58 ± 18 | 0.18 |
| Triglyceride (mg/dl)* | 81 (57–113) | 91 (68–132) | <0.01 |
| LDL cholesterol (mg/dl) | 109 ± 32 | 112 ± 32 | 0.28 |
| Serum creatinine (mg/dl) | 0.80 ± 0.16 | 0.88 ± 0.44 | <0.01 |
| Ever smoked, n (%) | 48 (38) | 1007 (37) | 0.77 |
*Non-normally distributed, reported as median (25th to 75th percentile).