Table 1.
Baseline characteristics of participants in AGES-Reykjavik and COPDGene stratified by ILA status and race.*
| AGES-Reykjavik | P-value | COPDGene Non-Hispanic Whites | P-value | COPDGene African-Americans | P-value | ||||
|---|---|---|---|---|---|---|---|---|---|
| No ILA (N=3209) |
ILA (N=377) |
No ILA (N=3667) |
ILA (N=485) |
No ILA (N=1728) |
ILA (N=223) |
||||
| Age – yrs | 76 ± 5 | 78 ± 6 | <.0001 | 61 ± 9 | 64 ± 10 | <.0001 | 54 ± 7 | 55 ± 8 | 0.003 |
| Gender – no. female(%) | 1905 (59) | 171 (45) | <.0001 | 1752 (48) | 219 (45) | 0.29 | 705 (41) | 126 (57) | <.0001 |
| Body Mass Index | 27 ± 4 | 27 ± 5 | 0.50 | 29 ± 6 | 29 ± 6 | 0.25 | 29 ± 7 | 29 ± 7 | 0.33 |
| Pack Years Smoking, median (IQR)† | 2‡ (0, 25) |
20‡ (0, 50) |
<.0001 | 40 (29, 56) |
45 (34, 63) |
<.0001 | 34 (22, 46) |
35 (24, 47) |
0.49 |
| Current Smokers – no. yes (%) | 373 (12) | 69 (18) | 0.0003 | 1402 (38) | 2546 (53) | <.0001 | 1393 (81) | 183 (82) | 0.65 |
| History of COPD§ – no. (%) | – | – | – | 1474 (40) | 167 (35) | 0.02 | 381 (22) | 54 (25) | 0.44 |
| Percentage of the lung less than −950 Hounsfield Units, median (IQR) | – | – | – | 3 (0.9, 9) |
1.4 (0.5, 4.8) |
<.0001 | 1.1 (0.4, 3.3) |
0.7 (0.2, 2.4) |
<.0001 |
*
ILA is interstitial lung abnormality, ± values are means and standard deviations.
†
IQR is interquartile range
‡
Includes cigarette and cigar smoking
§
COPD is chronic obstructive pulmonary disease