Table 3.

MUC5B Genotype and Interstitial Lung Abnormality Prediction^*

	MUC5B Minor Allele		Clinical Data†		Clinical Data + MUC5B Minor Allele		P-value for the comparison of Clinical to Clinical + MUC5B
	C-Statistic (95% CI)	P-Value	C-Statistic (95% CI)	P-Value	C-Statistic (95% CI)	P-Value
AGES-Reykjavik
ILA	0.61 (0.59, 0.64)	<.0001	0.64 (0.61, 0.66)	<.0001	0.72 (0.69, 0.74)	<.0001	<.0001
Subpleural & Radiologic ILD‡	0.63 (0.60, 0.67)	<.0001	0.66 (0.63, 0.70)	<.0001	0.72 (0.69, 0.76)	<.0001	<.0001
Definite Fibrosis§	0.64 (0.60, 0.69)	<.0001	0.70 (0.65, 0.75)	<.0001	0.75 (0.70, 0.79)	<.0001	0.004
Possible UIP & UIPǁ	0.64 (0.61, 0.67)	<.0001	0.64 (0.61, 0.68)	<.0001	0.72 (0.69, 0.75)	<.0001	0.001
Non-Hispanic Whites – COPDGene
ILA	0.54 (0.52, 0.62)	<.0001	0.57 (0.55, 0.60)	<.0001	0.58 (0.56, 0.61)	<.0001	0.20
Subpleural & Radiologic ILD	0.60 (0.57, 0.63)	<.0001	0.72 (0.69, 0.75)	<.0001	0.75 (0.72, 0.78)	<.0001	0.0006
Definite Fibrosis	0.57 (0.52, 0.62)	<.0001	0.76 (0.71, 0.80)	<.0001	0.76 (0.72, 0.81)	<.0001	0.22
Possible UIP & UIP	0.60 (0.57, 0.63)	<.0001	0.71 (0.68, 0.75)	<.0001	0.75 (0.72, 0.78)	<.0001	0.0008
African-Americans – COPDGene
ILA	0.51 (0.49, 0.52)	0.3	0.58 (0.54, 0.62)	0.0006	0.59 (0.55, 0.62)	0.0001	0.52
Subpleural & Radiologic ILD	0.52 (0.49, 0.55)	0.1	0.67 (0.62, 0.74)	<.0001	0.59 (0.55, 0.62)	<.0001	0.47
Definite Fibrosis	0.58 (0.50, 0.65)	0.0005	0.67 (0.62, 0.74)	<.0001	0.73 (0.62, 0.85)	0.005	0.34
Possible UIP & UIP	0.52 (0.49, 0.56)	0.06	0.69 (0.63, 0.77)	<.0001	0.70 (0.63, 0.76)	<.0001	0.50

^*ILA is interstitial lung abnormality; analyses using the MUC5B genotype were performed using additive genetic models.

^†Clinical Data includes age, sex and pack-years of tobacco exposure

^‡ILD is interstitial lung disease

^§Definite Fibrosis is evidence pulmonary parenchymal architectural distortion

^ǁUIP is usual interstitial pneumonia