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. Author manuscript; available in PMC: 2018 Nov 6.
Published in final edited form as: Dev Cell. 2017 Oct 26;43(3):318–331.e5. doi: 10.1016/j.devcel.2017.09.026

Figure 7. Ectopic signaling through Fgf9/Fgfr2-IIIc is responsible for the lateral cochlear wall defects in Esrp1 mutants.

Figure 7

(A–U) Transverse sections through the cochlear duct of control (n=15), Esrp1−/− (n=7) and Esrp1−/−;Fgf9+/− (n=6) embryos at E18.5 immunostained for E-cadherin (A,H,O), Otx2 (B,I,P) and cell type specific markers of the stria vascularis (C–G, J–N, Q–U). Scale bars = 50μm. (V) Quantification of cells expressing Otx2 and Nr3b2 represented as mean ± SD (***P<0.0001, ANOVA with Tukey’s test). (W) Schematic representation of the lateral cochlear wall phenotypes manifesting from altered Fgf signaling in Fgf10−/− and Esrp1−/− mutants compared to a control embryo. See also Figure S6.