Table 2.

Shared stress pathways and cellular aberrations that induce NKG2D ligands or NK responses in cancer and in infections

	Citations
Stress Pathway/aberration	Cancer	Infection
DNA damage response	(25, 79)	(57–59)
Proliferative signals	(26, 27)	?
Activated PI-3 kinase	(60, 77)	(60)
p53	(31)	?
Integrated stress response (ER stress, amino acid starvation)	(47, 49)	?
Heat shock stress	(27–30)	?
Reduced HDAC function	(25, 74)	(66)
Cytosolic DNA sensor in immune cell activation	(69, 81), (Marcus et al, submitted)	(33–36)