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dNSP16 mutation attenuates the virulence of a mouse-adapted MERS-CoV strain. Graphs show weight losses (A), day 4 viral titers (B), and hemorrhage scores (C) following infection of 288-330+/+ CRISPR-Cas9-targeted mice infected with 106 PFU of MERS-CoV MA1 (black) or dNSP16 MA1 (red) at days 2 and 4. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (Student t test). n = ≥3 for each group at each time point in two experiments.
