FIG 2 .

Genome-wide location of Snf6 and transcriptional profiling of snf6 mutant. (A) Gene ontology of biological process associated with Snf6-bound promoters. The P values were calculated using hypergeometric distribution as described in the GO Term Finder Tool website (http://candidagenome.org/cgi-bin/GO/goTermFinder). (B) Gene ontology analysis of upregulated transcripts of snf6/Tet-SNF6 mutant under repressible conditions. Cells were grown in YPD in the presence or absence of 40 µg/ml doxycycline for 48 h and analyzed for gene expression profiles by DNA microarrays. Snf6-dependent transcripts were obtained by comparing the transcriptome of mutant cells treated with doxycycline to that of nontreated cells and by applying a 1.5-fold change cutoff and Welch’s t test with a false discovery rate of less than 5%. (C) Venn diagram showing overlaps among genes differentially regulated in the snf6/Tet-SNF6 mutant and promoters bound by Snf6 under yeast-promoting conditions.