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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Antiviral Res. 2017 Oct 28;148:1–4. doi: 10.1016/j.antiviral.2017.10.019

Table 1.

Genotypes and phenotypes of recombinant viruses

Strain Genotype Letermovir
EC501 SD2 N3 Fold4 Δ5
Control Strains
4190 WT UL56 Frt 3.7 0.77 79
4272 WT UL89 Frt 3.5 0.65 26
4194 UL56 V231L 21 3.4 81 5.6
4296 UL56 V236M 115 13 11 32
4192 UL56 L241P 633 136 25 173
4315 UL56 R369M 60 8.6 20 16
4274 UL89 D344E 5.5 1.1 24 1.6
Newly Phenotyped Mutants
4244 UL56 S229F 6.6 1.1 11 1.8
4324 UL56 S229F L254F L257I 198 25 12 54
4292 UL56 L254F 12 2.1 10 3.2
4346 UL56 L257F 31 6.1 10 8.6
4312 UL56 N368D 7.4 1.5 10 2.0
4317 UL51 P91S 7.6 1.7 43 2.1
4318 UL51 P91S UL56 S229F 23 3.3 10 6.3 3.5
4348 UL51 P91S UL56 S229F L254F L257I 1060 137 12 290 5.4
4319 UL51 P91S UL56 V236M 101 10 10 28 0.9
4325 UL51 P91S UL56 R369M 460 53 10 126 7.7
4400 UL51 P91S UL89 D344E 14 1.2 17 4.0 2.6
1

Mean letermovir EC50 in nM

2

Standard deviation of EC50 values

3

Number of replicates (performed on at least 4 separate dates)

4

Ratio of EC50 value to that of wild type control strain (values >1.5 in bold)

5

Fold change in EC50 value resulting from addition of UL51 P91S to UL56 or UL89 mutation