Table 2.

Preceding and concurrent longitudinal change (in μm) in exploratory measures in knees with and without radiographic progression and knees with and without symptomatic progression

	No Progression			Progression
	Mean ± SD	95% CI	SRM	Mean ± SD	95% CI	SRM	P-Value	OR [95% CI]
Symptomatic progression:
Preceding change (BL→Y2):
MFTC	−78 ± 188	[−93, −62]	−0.41	−87 ± 186	[−113, −62]	−0.47	0.593	1.0 [0.8, 1.1]
mOV1	−204 ± 192	[−220, −189]		−207 ± 175	[−231, −183]		0.291	0.9 [0.8, 1.1]
mOV8	114 ± 99	[106, 122]		104 ± 84	[92, 115]		0.308	0.9 [0.8, 1.1]
mThinning	−546 ± 575	[−593, −498]		−565 ± 585	[−645, −484]		0.399	0.9 [0.8, 1.1]
mThickening	258 ± 238	[238, 277]		236 ± 216	[206, 265]		0.462	0.9 [0.8, 1.1]
mJSW	−272 ± 618	[−323, −221]	−0.44	−243 ± 497	[−312, −175]	−0.49	0.234	0.9 [0.8, 1.1]
Concurrent change (Y2→Y4)
MFTC	−78 ± 209	[−96, −60]	−0.37	−188 ± 294	[−231, −146]	−0.64	<0.001	1.6 [1.3, 1.9]
mOV1	−202 ± 203	[−220, −185]		−312 ± 299	[−355, −270]		<0.001	1.6 [1.3, 1.9]
mOV8	110 ± 88	[102, 118]		93 ± 91	[80, 106]		0.018	0.8 [0.7, 1.0]
mThinning	−550 ± 676	[−609, −492]		−909 ± 987	[−1051, −768]		<0.001	1.6 [1.3, 1.9]
mThickening	256 ± 242	[235, 277]		200 ± 215	[169, 231]		0.011	0.8 [0.6, 0.9]
mJSW	−300 ±620	[−353, −246]	−0.50	−626 ± 853	[−748, −503]	−0.74	<0.001	1.5 [1.3, 1.8]
Radiographic progression:
Preceding change (BL→Y2):
MFTC	−65 ± 172	[−79, −51]	−0.38	−136 ± 228	[−171, −101]	−0.60	<0.001	1.3 [1.1, 1.6]
mOV1	−190 ± 169	[−204, −177]		−259 ± 236	[−296, −223]		<0.001	1.3 [1.1, 1.5]
mOV8	115 ± 96	[107, 123]		98 ± 90	[85, 112]		0.136	0.9 [0.7, 1.0]
mThinning	−507 ± 520	[−548, −465]		−713 ± 733	[−825, −601]		0.002	1.3 [1.1, 1.5]
mThickening	260 ± 236	[242, 279]		220 ± 216	[187, 253]		0.166	0.9 [0.7, 1.1]
Concurrent change (Y2→Y4):
MFTC	−52 ± 165	[−66, −38]	−0.31	−307 ± 339	[−360, −253]	−0.90	<0.001	3.0 [2.4, 3.9]
mOV1	−172 ± 147	[−184, −160]		−444 ± 351	[−499, −388]		<0.001	3.3 [2.5, 4.2]
mOV8	109 ± 85	[102, 116]		93 ± 101	[77, 109]		0.093	0.9 [0.7, 1.0]
mThinning	−457 ± 502	[−499, −415]		−1321 ± 1165	[−1506, −1136]		<0.001	3.1 [2.4, 3.9]
mThickening	257 ± 243	[237, 278]		182 ± 202	[150, 215]		0.011	0.7 [0.6, 0.9]

Symptomatic progression was defined as increase of ≥9 points on the Western Ontario and McMaster Universities (WOMAC) pain index (scale: 0 … 100) between the year 2 (Y2) and the year 4 (Y4) follow-up visit; Radiographic progression was defined as a decrease of ≥0.7mm in minimum radiographic joint space width in the medial compartment (mJSW) between the Y2 and the Y4 follow-up visit; the number of knees with/without symptomatic or radiographic progression is shown in Table 1; BL: Baseline; SD: Standard deviation of the change; 95% CI: 95% confidence intervals of the change; P-Value: Computed using analysis of covariance with adjustment for sex, age, BMI, WOMAC pain, medial joint space narrowing at the respective reference visit (BL or Y2); OR: Odds ratio without adjustment or with adjustment for sex, age, BMI, WOMAC pain, medial joint space narrowing at the respective reference visit (BL or Y2); MFTC: Medial femorotibial compartment; mOV1/8: Medial compartment ordered value 1/8; mThinning/mThickening: Thinning/Thickening sum score of subregional changes in the medial compartment. Change in mJSW was only provided for the comparison between knees without and knees with symptomatic progression. Please note that the concurrent change in mJSW deviates slightly from the change shown in table 1, because the concurrent change was computed for the knees that also had MRI cartilage thickness measurements at Y4.