Table 3.

eQTL analysis of candidate SNPs in the Finnish cohort.

Outcome	Recipient/Donor	Gene*	SNP	CHR	A1	Risk/protective†	cis-eQTL gene‡	Z-score‡	P ‡	FDR‡
aGvHD	Recipient + donor	MICD	rs2523957	6	G	Risk	HLA-F	15.64	3.65 × 10–55	<0.01
							HLA-G	−13.89	7.18 × 10−44	<0.01
							PPP1R11	−9.09	1.03 × 10−19	<0.01
							ZNRD1	5.44	5.27 × 10−8	<0.01
aGvHD	Recipient	PRSS53/VKRC1	rs7294	16	T	Risk	STX4	16.17	8.85 × 10−59	<0.01
							BCKDK	−11.27	1.82 × 10−29	<0.01
							ZNF668	−10.78	4.12 × 10−27	<0.01
							AC093520.4, ITGAM	−6.26	3.73 × 10−10	<0.01
							AC135050.5	−5.95	2.68 × 10−9	<0.01
							MYST1	5.58	2.38 × 10−8	<0.01
aGvHD	Donor	IL1R1	rs3917225	2	A	Risk	IL1R2	3.36	7.73 × 10−4	0.20
aGvHD	Donor	TNF	rs1800629	6	A	Risk	TNF	−5.28	1.28 × 10−7	<0.01
							CSNK2B	5.17	2.29 × 10−7	<0.01
							LTA	−3.21	1.31 × 10−3	0.29
aGvHD	Donor	NFKBIA	rs2233409	14	A	Risk	—	—	—	—
cGvHD	Recipient	IL1B	rs16944	2	A	Risk	NT5DC4	3.2	1.36 × 10−3	0.30
cGvHD	Recipient	NOD2	rs6500328	16	G	Risk	NOD2	−22.76	1.10 × 10−114	<0.01
cGvHD	Donor	HSPA1L	rs2075800	6	T	Protective	CSNK2B	−22.03	1.47 × 10−107	<0.01
							HSPA1B	20.06	1.78 × 10−89	<0.01
							HSPA1L	8.17	3.02 × 10−16	<0.01
							LY6G5C	5.64	1.75 × 10−8	<0.01
							RDBP	5.62	1.90 × 10−8	<0.01
							AIF1	5.35	8.77 × 10−8	<0.01
							BAT3	4.52	6.13 × 10−6	<0.01
cGvHD	Donor	KRAS	rs1137282	12	G	Protective	—	—	—	—

SNP indicates single nucleotide polymorphism; CHR, chromosome; A1, minor allele; eQTL indicates expressive quantitative trait loci; FDR, false detection rate; aGvHD, acute graft-versus-host disease grade III–IV; −, no cis-eQTL records found; and cGvHD, extensive chronic graft-versus-host disease.

*Annotation of SNP according to National Center for Biotechnology Information dbSNP database.

^†Risk/protective outcome status of the SNP has been determined from the association results (Table 1).

^‡Westra et al. ¹⁶. Blood eQTL Browser http://genenetwork.nl/bloodeqtlbrowser/.