Fig. 3.
Genetically driven correlation of CpG methylation with PIGP gene expression. The a correlation of PIGP 3′-expression with methylation states of CpG cg21832243 in the promoter flanking region (explained variance: 33.5%) is based on b a cis-eQTL (ILMN_1774949; P = 1.44 × 10−22, explained variance: 57.1%) and c a cis-meQTL (cg21832243; P = 9.58 × 10−20, explained variance: 50.9%) both driven by a shared SNP rs9974798. Previously, we reported an association of the SNP rs9305614 in the PIGP promoter with pharmacoresistance of seizures for the antiepileptic drug levetiracetam in a partial overlapping sample of TLE patients70