Fig. 3.

Amphipathic domains in IRI-active compounds. a Safranin O⁵³; b Solution NMR structure of AFGP-8⁵⁹; c Postulated structure of ZrOAc⁵⁶; d Nisin A simulation with hydrophilic (red) and hydrophobic (blue) domains indicated⁵⁸; e Modulation of Nisin A IRI by solution pH. a is adapted with permission from Drori et al. (2016)⁵³. Copyright (2016) American Chemical Society. This image is not included under the creative commons licence for this article. b is reproduced from Tachibana et al. (2004)⁴³. Copyright (2004) WILEY-VCH Verlag GmbH & Co.KGaA, Weinheim. This image is not included under the creative commons licence for this article. c is reproduced from Mizrahy et al. (2013)⁵⁶ published under CC-BY4.0 at PLOS. d, e are reproduced from Mitchell et al., (2015)⁵⁸ published under CC-BY4.0 at ACS