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. 2017 Nov 15;7:15680. doi: 10.1038/s41598-017-15947-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of subsampling SNPs on r² relative to position. From the original 9541 SNPs on chromosome 1, random subsampling was performed, reducing the number of SNPs from 9000 to 1500 in 6 steps of 1500. In each step, 10 subsets were randomly sampled (without replacement). The number of SNPs that were polymorphic is depicted in the graph. At 4500 SNPs, WES and cHD had an equal number of informative tagSNPs (WES: 3310 SNPs, cHD: 3365 SNPs). Lines are obtained with LOWESS (locally weighed scatterplot smoothing).