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. 2017 Nov 15;7:15650. doi: 10.1038/s41598-017-15834-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Na_V1.3 is necessary for EC cell action potentials. (A,B) Typical action potentials from small bowel (A) and colon (B) EC cells, elicited by 50-ms depolarizing current steps (bottom). (C,D) Elicited EC cell action potentials were blocked by Na⁺ ion replacement (C) or Na_V1.3 inhibition using ICA-121431 (300 nM, as highlighted by # in Fig. 4F). (D) Insets, first derivatives of the traces in each panel, showing the rate of change in membrane potential induced by the current injection protocol. The maximum depolarization rate is an approximate measure of the inward current through voltage-gated sodium channels.