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. 2017 Nov 15;7:15645. doi: 10.1038/s41598-017-15154-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SR141716A ameliorates metabolic dysfunction in diet-induced obesity. Experiments Diet-Induced Obesity (DIO)were set up as described in Fig. 1 legend. (a) Glucose tolerance test (GTT) and (b) Insulin tolerance test (ITT) of mice fed LFD + Vehicle (n = 10), HFD + Vehicle (n = 10), HFD + SR (n = 9) and Pair-fed to SR141716A (PFSR) (n = 10). Each animal received by oral gavage 1.5 g/kg body mass of glucose (25% D-glucose). Blood glucose levels were determined after 15, 30, 60 and 120 minutes. Insulin-tolerance tests were carried out on un-fasted animals by i.p injection of 1.5 U/kg body mass of insulin. Blood glucose levels were detected after 15, 30, 60 and 120 minutes. Generalized Linear Mixed Model (GLMM) was performed to calculate p values for the repeated measures in SPSS. Mean Area Under the Curve (AUC) from triplicate experiments measured between 0–120 minutes after glucose (GTT) and insulin (ITT) load. AUC was assessed with Trapezoidal rule in R software. Data with different superscript letters are significantly different. GTT (P < 0.01), ITT (P < 0.05).