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. 2017 Nov 15;7:15645. doi: 10.1038/s41598-017-15154-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SR141716A restores gut barrier function in diet-induced obesity. Experiments Diet-Induced Obesity (DIO) were set up as described in Fig. 1 legend. (a) Representative Periodic Acid Schiff images were used for in situ mucus layer staining, scale bar,100 μm. (b) Thickness of the mucus layer measured by histological image analysis software MetaMorph (LFD + Vehicle, n = 5; HFD + Vehicle, n = 5; SR, n = 6; PFSR, n = 5; and BWM, n = 6). (c–e) mRNA expression analysis by qRT-PCR of mucus-related genes in the colonic mucosa. (f) Intestinal permeability was measured by quantitation of levels of serum FITC-Dextran (4 kDa) following oral gavage (n = 5 except LFD + Vehicle, n = 4). (g) Plasma lipopolysaccharide (LPS) level in Diet-Induced Obesity (DIO) mice treated with SR141716A for four weeks and controls was quantified (n = 5). (h) Myeloperoxidase (MPO) levels in colonic tissue were measured (n = 5). Data are shown as mean $\pm$ SD. Data with different superscript letters are significantly different (P < 0.05) according to post hoc ANOVA one-way statistical analysis.