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. 2017 Nov 15;7:15645. doi: 10.1038/s41598-017-15154-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SR141716A attenuates overactivity of endocannabinoid system in diet-induced obesity. Experiments Diet-Induced Obesity (DIO) were set up as described in Fig. 1 legend. (a) Adipose tissue CB1 mRNA levels in SR141716A-treated Diet-Induced Obesity (DIO) (HFD + SR), vehicle-treated Diet-Induced Obesity (DIO) (HFD + Vehicle), lean mice (LFD + Vehicle) and Pair-fed to SR141716A (PFSR) control mice was assessed by RT-PCR. (b) White adipose tissue AEA levels from the same mice (percent of control values) were measured with Liquid Chromatograph/Mass Spectrometry/Mass Spectrometry (LC/MS/MS) (n = 3). N-archidonoylethanolamine (AEA) levels (percent of LFD + Vehicle) were calculated in the epididymal adipose tissue of HFD + SR, HFD + Vehicle, and PFSR (n = 3). Data are shown as mean $\pm$ SD. Data with different superscript letters are significantly different (P < 0.05) according to post hoc ANOVA one-way statistical analysis.