Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 15;7:15638. doi: 10.1038/s41598-017-15715-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

CDC73-NTD harbors all reported pathogenic missense mutations. (a) Domain structure of CDC73 shows that four characterized pathogenic mutations are clustered in CDC73-NTD. (b) Positions of those four pathogenic missense mutations are labeled in the structure of CDC73-NTD. (c) Sequence alignment of CDC73(1–111) from ten species shows that CDC73-NTD is evolutionarily conserved from yeast to human. The indicate positions of CDC73 pathogenic missense mutations. The ▴ mark residues forming the hydrophobic groove of CDC73-NTD.

Inline graphic — CDC73-NTD harbors all reported pathogenic missense mutations. (a) Domain structure of CDC73 shows that four characterized pathogenic mutations are clustered in CDC73-NTD. (b) Positions of those four pathogenic missense mutations are labeled in the structure of CDC73-NTD. (c) Sequence alignment of CDC73(1–111) from ten species shows that CDC73-NTD is evolutionarily conserved from yeast to human. The indicate positions of CDC73 pathogenic missense mutations. The ▴ mark residues forming the hydrophobic groove of CDC73-NTD.