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. 2017 Nov 15;8:1527. doi: 10.1038/s41467-017-01657-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Reported HAT inhibitors perturb the La antigen conformation as assessed by ALARM NMR. Compounds tested at 400 μM final concentrations. Signal intensities (z-axis, relative units) normalized to DMSO control. Dashed border, positive readout. CPM (N-[4-(7-diethylamino-4-methylcoumarin-3-yl)phenyl]maleimide), positive thiol-reactive compound control; fluconazole, negative thiol-reactive and aggregation compound control. Note treatment of the La antigen with compound 17 results in several new peaks independent of DTT (arrowheads). Data are representative results from one experiment performed with two technical replicates. See Table 1 for additional results and interpretations